ตัวอย่างของหัวข้องานวิจัยที่ ผศ.ภก.ดร.เกรียงศักดิ์ ดำเนินการไปแล้วและทำวิจัยอยู่

                               

สิทธิบัตร

ได้รับการจดสิทธิบัตร เรื่อง “สารผสมของยาเพื่อยับยั้งเชื้อ Staphylococcus aureus และเชื้อ Enterobacter cloacae ที่ดื้อต่อยาปฏิชีวนะ” เลขที่คำขอสิทธิบัตร เลขที่ 0601001839

 

เมธีวิจัย สกว.

ได้รับคัดเลือกเป็น เมธีวิจัย สกว. ภายใต้โครงการวิจัย “การวิจัยและพัฒนายาต้านเชื้อแบคทีเรียสูตรใหม่ สำหรับการรักษาเชื้อแบคทีเรียดื้อยา” (Research and development new antibacterial drug for  treatment of drug resistant bacteria)

ประสบการณ์ที่เกี่ยวข้องกับงานวิจัยทั้งภายในและภายนอกประเทศ (บางส่วน)
 

1. Reversing b-lactam antibiotic resistance with flavonoids in Gram positive Bacteria
2. The study of antibacterial activity of some medicinal plants in Lamiaceae Family
3. Toxicity of Bacillus thruingiensis var israelensis towards Aedes aegypti larvae in various water containers and under different environmental conditions.
4. Comparison of the toxicity effect of neem extract and some Thai medicinal plants on house fly larvae
5. Study of Antibacterial effect of crude extract from some Thai medicinal plants in Zingiberaceae Family on some drug resistant bacteria
6. The study of medicinal plants and supplement food for health of community in NakhonRatchasima province
7. The effect of some medicinal plant extracts in Asteraceae Family on Xanthomonas campestris pv.glycines (Nakano)Dye causing bacterial pustule on soybean.
8. Trends in needs of biomedical science program 

9. Investigation of the effect of galangin on some b-lactam antibiotics resistant bacteria

10. In vivo toxicity test of galangin

11. Investigation of the effect of some flavonoids on some b-lactam antibiotics resistant bacteria

12. In vivo toxicity test of some flavonoids

13. Research and development of new antibacterial for treatment of resistant bacteria (เมธีวิจัย สกว)

14. Antibacterial activity of the pericarp of Garcinia mangostana against drug resistant bacteria

15. The antibacterial activity of serum from the Thai crocodile (Crocodylus siamensis) on drug resistant bacteria

16. Bioactive Compounds form the Tuberous Roots of Butea superba Roxb.

17. Optimal dose and toxicity test of Flavonoids isolated from the tuberous Roots of Butea superba Roxb in male rat.

18. Effect of flavonoids on lower blood lipid levels in hyperlipidemic mice

 

Current Professional Field Registration:
Clinical Pharmacology and toxicology, Medicinal plant, Clinical Pharmacy

Members:
1. Thai society of toxicology
2. Thai society of pharmacist
3. Thai pharmacy council
4. The alumni association of Faculty of Pharmaceutical Sciences, Chulalongkorn
University.

Research Grants Awarded:
2015- The Research and Researchers for Industries-RRi Ph.D. Program Advisorships (1 Grant): The Thailand Research Fund,  Thailand

2013- The Royal Golden Jubilee Ph.D. Program Advisorships (1 Grant): The Thailand Research Fund,  Thailand

2012: The Royal Golden Jubilee Ph.D. Program Advisorships (1 Grant): The Thailand Research Fund, Thailand

2011: The Royal Golden Jubilee Ph.D. Program Advisorships (1 Grant): The Thailand Research Fund, Thailand
2006-2008: Research Career Development Grant (Metheevijai): The Thailand Research
Fund, Thailand
2003-2004: Research Grant for New Scholar : The Thailand Research Fund-Commission on
Higher Education
2004-2013: Research Grants (10 Grants): National Research Council of Thailand/Institute of
Research and Development, Suranaree University of Technology, Thailand


Award :

 

2013 : Outstanding alumnus, Nonkipittakom school, Burirum, Thailand

2011 : Renowned deed in athletics leader, Suranaree University of Technology
2010 : Renowned deed in athletics manager, Suranaree University of Technology
2008 : Outstanding alumnus, Nonkipittakom school, Burirum, Thailand
2004 : Renowed Needle of Honor of the Queen Mother academic Olympics.

1994-1999: The Royal Thai Government Scholarship, MUA, to study Ph.D.
in U.K. for 4 years.
1985-1988: Boonrod - Brewery Scholarship for 4 years, Chulalongkorn University,
1983-1984: Bangkok-Bank Scholarship for 2 years, Mahidol University

Scientific Publications :
Referred articles:

Richards, R.M.E., Eumkeb, G.and Marshall, D. (1997). Is the ultrastructural damage caused by subinhibitory concentrations of trimethoprim and sulphadiazine part of their normal mechanism of action? Microbios, 92, 183 - 197.

Eumkeb, G. and Richards, R.M.E. (2005). Reversing beta-lactam antibiotic resistance with flavonoids in Gram positive Bacteria. Acta Horticulturae. Vol 4: 678: 171-178.

Jirawan Oonmetta-aree, Tomoko Suzuki, Piyawan Gasaluck and Griangsak Eumkeb. (2006). Antimicrobial Properties and Action of Galangal (Alpinia galanga Linn.) on Staphylococcus aureus. LWT Food Science and Technology. 39: 1214-1220.
(IF 2014 = 2.416) 

Punopas, K., Eumkeb, G., Chitsomboon, B. and Nakkiew, P. (2004). The study of antibacterial activity of some medicinal plant in Lamiaceae family. Suranaree J. Sci. Technol. 11:52-59.

Eumkeb, G. and Richards R.M.E. (2004). Reversing b-Lactam Antibiotic Resistance in Gram- positive bacteria by Some Flavonoids. Suranaree J. Sci. Technol. 11:143-150.

Eumkeb, G., Sakdarat, S and Siriwong, S. (2010). Reversing b-lactam antibiotic resistance of Staphylococcus aureus with galangin from Alpinia officinarum Hance and synergism with ceftazidime. Phytomedicine 18(1): 40-45.
(Impact Factor 2014 = 3.216) 

Eumkeb, G. and Duangkham A. (2011). Subacute Toxicify Test of Galangin and ceftazidime in Mice. Thai Journal of Toxicology 26(1): 5-13.

Eumkeb, G., Siriwong, S., Phitaktim, S., Rojtinnakorn, N., Sakdarat, S. (2012). Synergistic activity and mode of action of flavonoids isolated from smaller galangal and amoxicillin combinations against amoxicillin-resistant Escherichia coli. J. Appl. Microbiol. 112, 55-64.
(Impact Factor 2014 = 2.479) 

Munglue, P., Eumkep, G., Wray, S., Kupittayanant, S., 2012. The Effects of Watermelon (Citrullus lanatus) Extracts and L-Citrulline on Rat Uterine Contractility. Reproductive Sciences. 20, 437-448.
(Impact Factor 2014 = 2.230) 

Eumkeb, G., Siriwong, S., Thumanu, K., 2012. Synergistic activity of luteolin and amoxicillin combination against amoxicillin-resistant Escherichia coli and mode of action. Journal of Photochemistry and Photobiology B: Biology. 117, 247-253.
(Impact Factor 2014 = 2.960)  

Eumkeb, G., Chukrathok, S., 2012. Synergistic activity and mechanism of action of ceftazidime and apigenin combination against ceftazidime-resistant Enterobacter cloacae. Phytomedicine. 20, 262-269. 
(Impact Factor 2014 = 3.216) 
 

Teethaisong, Y., Autarkool, N., Sirichaiwetchakoon, K., Krubphachaya, P., Kupittayanant, S. and Eumkeb, G., 2014. Synergistic activity and mechanism of action of Stephania suberosa Forman extract and ampicillin combination against ampicillin-resistant Staphylococcus aureus. J Biomed Sci 21:90 (Impact Factor 2014 = 2.763).

Siriwong, S., Pimchan, T., Naknarong, W. and Eumkeb, G., 2015. Mode of action and synergy of ceftazidime plus baicalein against Streptococcus pyogenes. Tropical Journal of Pharmaceutical Research. 14, 641-648.          (Impact Factor 2014 = 0.589).

 

Patent

The combination of flavonoids and drugs against Staphylococcus aureus and Enterobacter cloacae : patent asking no: 0601001839 , 2006

Conference Proceedings:

Griangsak Eumkeb, Nichayanan Chaisena, Nitaya Rojtinnakorn, Supatcharee Siriwong, Aphai Duangkham. (2008). P14 Reversing b-Lactam Antibiotic Resistant Bacteria with Flavonoids. In : Proceeding of 30th Pharmacological and Therapeutic Society of Thailand Meeting. 27-28 March 2008. Thai Journal of Pharmacology. Vol 29: No I: 117-126. Bangkok: Ruen Kaew Press.

Siriwong S, Thumanu K, Eumkeb G. (2010). Using FT-IR microspectroscopy to investigate biochemical change of drugs-resistance Escherichia coli treated with amoxicillin and apigenin. In: Proceeding of the 36th Congress on Science and Technology of Thailand (STT36). Abstract Book (Oral presentation, B2_0051/pp70.) 26-28 October 2010, Bangkok, Thailand: Bangkok International Trade & Exhibition Centre (BITEC), Thailand.

Munglue, P., Eumkep, G., Wray, S., Kupittayanant, S., (2012). Uterine Relaxant Effects of Watermelon (Citrullus lanatus) Extracts. , in: The Physiology Society, (Ed.), Physiology 2012. The Physiology Society, Edinburgh International Conference Center, Edinburgh, EH3 8EE, United Kingdom., 27, pp. PC364.

Siriwong, S., Eumkeb, G., 2012. Synergistic effect of penicillin with apigenin and kaempferol against Penicillin-resistant Staphylococcus epidermidis, in: Manosroi, A., Manosroi, J. (Ed.), NATPRO 4, Natural Products for Health and Beauty, The Fourth International Conference on Natural Products for Health and Beauty. Sangreeya Publishing Co., Chiang Mai, Thailand, pp. 368-372.

Naknarong, W., Eumkeb, G., 2012. The effects of Red Kwao Kreu (Butea superba Roxb.) extract on reproductive system of male mice, in: Manosroi, A., Manosroi, J. (Ed.), NATPRO 4, Natural Products for Health and Beauty, The Fourth International Conference on Natural Products for Health and Beauty. Sangreeya Publishing Co, Chiang Mai, Thailand, pp. 193-197.

Eumkeb, G., Phitaktim, S. and Teethaisong, Y. (2013). "Antibacterial Activity of α-Mangostin from the Pericarp Extract of Garcinia mangostana L. against Drug Resistant Bacteria." Proceedings of the 30th Annual Research Conference in Pharmaceutical Sciences. Thai J. Pharm. Sci. 38 (Suppl): 83-87.

 

 

Eumkeb, G., Naknarong, W. and Sirichaiwetchakoon, K. (2013). "The effects of Red Kwao krue (Butea superba Roxb.) extract on reproductive system of male mice." Proceedings of the 30th Annual Research Conference in Pharmaceutical Sciences. Thai J. Pharm. Sci. 38(Suppl): 120-123.

 

 

Siriwong S, Krubphachaya P., Thumanu K, Eumkeb G. (2013). "Synergy effect of ceftazidime with flavonoids against Streptococcus pyogenes." Proceedings of the 30th Annual Research Conference in Pharmaceutical Sciences. Thai J. Pharm. Sci. 38(Suppl): 115-118.

 

Autarkool, N., Teethaisong, Y., Kupittayanant, S., & Eumkeb, G. (2014, May 6-8, 2014). Antibacterial activity of Staphania suberosa extract against methicillin-resistant Staphylococcus aureus Paper presented at the The 5th International Conference on Natural Products for Health and Beauty (NATPRO 5), Moevenpick Resort & Spa Karon Beach Phuket, Thailand.

 

Rojtinnakorn, N., Kupittayanantb, S., Temsiripong, Y., & Eumkeb, G. (2014, May 6-8, 2014). Antibacterial activity of plasma fractions from  Siamese crocodile (Crocodylus siamensis) on Ceftazidime-resistant Enterobacter cloacae Paper presented at the The 5th International Conference on Natural Products for Health and Beauty (NATPRO 5), Moevenpick Resort & Spa Karon Beach Phuket, Thailand.

 

Eumkeb, G., Duangkham, A., & Hengpratom, T. (2014, May 6-8, 2014.). Subchronic toxicity test of quercetin and cloxacillin in mice. Paper presented at the The 5th International Conference on Natural Products for Health and Beauty (NATPRO 5), Moevenpick Resort & Spa Karon Beach Phuket, Thailand.

 

Teethaisong, Y., Autarkool, N., & Eumkeb, G. (2014, May 6-8, 2014). Synergistic antibacterial activity of Boesenbergia rotunda extract and β-lactam antibiotic combination against multidrug-resistant bacteria. Paper presented at the The 5th International Conference on Natural Products for Health and Beauty (NATPRO 5), Moevenpick Resort & Spa Karon Beach Phuket, Thailand.

 

Cheypratub, P., Leeanansaksiri, W., & Eumkeb, G. (2014, May 6-8, 2014). Antibacterial activity of Cyperus rotundus extract against Methicillin-resistant Staphylococcus aureus. Paper presented at the The 5th International Conference on Natural Products for Health and Beauty (NATPRO 5), Moevenpick Resort & Spa Karon Beach Phuket, Thailand

Research reports:

Eumkeb,G. and Jinakoon, N. (2003). The study of medicinal plants and supplement food for health of community in NakhonRatchasima province

Eumkeb, G., Duangkham, A., (2012). In vivo toxicity test of galangin. Suranaree University of Technology, NakhonRatchasima, pp. 38.

Eumkeb, G., Chukrathok, S., (2012). Investigation of the effect of galangin on some b-lactam antibiotics resistant bacteria. Suranaree University of Technology, NakhonRatchasima, pp. 33.

Eumkeb, G., Siriwong, S., (2012). Investigation of the effect of some flavonoids on some b-lactam antibiotics resistant bacteria. Suranaree University of Technology, NakhonRatchasima, pp. 57.

Eumkeb, G., Duangkham, A., 2012. In vivo toxicity test of some flavonoids. Suranaree University of Technology, NakhonRatchasima, pp. 59.

 

Technical articles (บทความทางวิชาการ)

Eumkeb, G., 2014. Galangal, From the kitchen to the pharmacy, The Siam Magazine. Siam I Am Co., Ltd., Nakhon Ratchasima, pp. 42-47.

 

Conference Abstracts:

Eumkeb, G. and Richards, R.M.E. (2003). Reversing b-lactam antibiotic resistance with flavonoids in Gram positive Bacteria. In The 3rd World Congress on Medicinal and Aromatic Plant for Human Welfare (WOCMAP III) From Biodiversity through Science and Technology, Trade and Industry to Sustainable Use, Abstracts Book (Poster presentation, PP04-59, pp.450). 3-7 February 2003, Chiangmai, Thailand : Chiangmai University

Eumkeb, G. and Richards, R.M.E. (2004). Reversing b-lactam antibiotic resistance in Gram positive Bacteria with some flavonoids. In :The 20th FAPA Congress 2004 : Emerging Science and Profession in Pharmacy , Abstracts Book (Oral presentation, PP-O-01, pp. 160). 30 Nov – 3 Dec 2004, Bangkok, Thailand : The Pharmaceutical Association of Thailand under Royal Patronage, Bangkok.

Eumkeb, G. (2005). Investigation of the effect of Some Flavonoids on some b-lactam antibiotics resistant bacteria. In :The Thai research Fund meeting : Senior Thai research Fund researchers meet Junior Thai research Fund researchers,
Abstracts Book (Poster presentation, MRG168/p225, pp. 214.) 14-16 January 2005, Kanchanaburee, Thailand : The Thai Research Fund and The higher education commission, Bangkok.

Eumkeb, G. (2005). Investigation of the effect of Some Flavonoids on some b-lactam antibiotics resistant bacteria. In :The Thai research Fund meeting : Senior Thai research Fund researchers meet Junior Thai research Fund researchers, Abstract Book (Oral presentation, 13-R1-S1-MRG4680168/p227, pp. 1) 13-15 October 2005, Petchaburi, Thailand : The Thai Research Fund and The higher education commission, Bangkok.

Eumkeb, G. Chukratok. S., Suttajit. M. and Ruangrungsi. N. (2005). Investigation of the effect of Some Flavonoids on some b-lactam antibiotics resistant bacteria. In :The 1st International Conference on Natural products for Health and Beauty; From local wisdom to global marketplace. Abstract Book (Oral presentation, O4-1/p232, pp. 124) 17-21 October 2005, Mahasarakham, Thailand : Mahasarakham University, and the higher education commission, Thailand.

Eumkeb, G., Wongkamsound, K (2007). Flavonoids synergy with b-lactam antibiotics against b-lactam-resistant bacteria. In :The Thai research Fund meeting : Senior Thai research Fund researchers meet Junior Thai research Fund researchers 7th, Abstract Book (Poster presentation, P-PHY-B06-RSA4980004 /p26 , pp. 26) 11-13 October 2007, Pattaya, Chonburee,Thailand : The Thai Research Fund and The higher education commission, Bangkok

Eumkeb, G., Wongkamsound, K. (2008). Flavonoids synergy with β-lactam antibiotics against β-lactam-resistant bacteria. The Thai research Fund meeting : Senior Thai research Fund researchers meet Junior Thai research Fund researchers, Abstract Book (Poster presentation, PS-BIO-E20) 16-18 October 2008, Cha-am, Petchaburi, Thailand, Thailand research fund and Commission on higher education: p. 144.

Eumkeb, G., Phitaktim, S., Rojtinnakorn, N., Siriwong, S., Duangkham, A.,Naknarong, W., Wisansawat, J. (2009). Flavonoids synergy with β-lactam antibiotics against β-lactam-resistant bacteria. The Thai research Fund meeting : Senior Thai research Fund researchers meet Junior Thai research Fund researchers, Abstract Book (Poster presentation, PS-BIO-B24) 15-17 October 2009, Cha-am, Petchaburi, Thailand, Thailand research fund and Commission on higher education: p. 105.

ผลงานตีพิมพ์ทางหนังสือพิมพ์และสื่ออินเตอร์เนต (บางส่วน)
 

เกรียงศักดิ์ เอื้อมเก็บ พัฒนาสารสกัด"ข่า"สู่ยาปฏิชีวนะสูตรใหม่ ยับยั้งเชื้อแบคทีเรียที่ทำให้เกิดหนอง สำนักงานกองทุนสนับสนุนการวิจัย วันที่ 14 มกราคม 2548
เกรียงศักดิ์ เอื้อมเก็บ วิจัยพบ"ข่า"ยาปฏิชีวนะสูตรใหม่ ผู้จัดการออนไลน์ วันที่ 15 มกราคม 2548 เวลา 12:39 น. http://www.manager.co.th/
เกรียงศักดิ์ เอื้อมเก็บ เร่งวิจัย"ข่า"เป็นยาปฏิชีวนะสูตรใหม่ ต้านเชื้อหนองดื้อยา หนังสือพิมพ์บ้านเมือง ประจำวันจันทร์ที่ 17 มกราคม 2548
เกรียงศักดิ์ เอื้อมเก็บ "ข่า"สยบเชื้อดื้อยา เล็งวิจัยสูตรใหม่ ผสมสารสมุนไพร หนังสือพิมพ์กรุงเทพธุรกิจ ประจำวันอังคารที่ 18 มกราคม 2548
เกรียงศักดิ์ เอื้อมเก็บ วิจัย"ข่า"ทำยาปราบเชื้อแบคทีเรียจอมดื้อ หนังสือพิมพ์ผู้จัดการรายวัน ประจำวันศุกร์ที่ 21 มกราคม 2548 หน้า 43.
เกรียงศักดิ์ เอื้อมเก็บ พัฒนาสารสกัดจาก"ข่า"แทนยาปฏิชีวนะสมัยใหม่ ยับยั้งเชื้อแบคทีเรียที่ทำให้เกิดหนอง หนังสือพิมพ์สยามรัฐ ประจำวันศุกร์ที่ 28 มกราคม 2548
เกรียงศักดิ์ เอื้อมเก็บ สารสกัด"ข่า"ส่วนผสมยาปฏิชีวนะสูตรใหม่ ต้านเชื้อหนองดื้อยา หนังสือพิมพ์โพสต์ทูเดย์ ประจำวันอาทิตย์ที่ 13 กุมภาพันธ์ 2548 หน้า B5.