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Induction of
apoptosis by xanthones from mangosteen in human leukemia cell lines.
Matsumoto K,
Akao Y,
Kobayashi E,
Ohguchi K,
Ito T,
Tanaka T,
Iinuma M,
Nozawa Y.
Gifu
International Institute of Biotechnology, 1-1 Naka-Fudogaoka, Kakamigahara, Gifu
504-0838, Japan. kmatsumoto@giib.or.jp
We examined the effects of six xanthones from the pericarps of mangosteen,
Garcinia mangostana, on the cell growth inhibition of human leukemia cell line
HL60. All xanthones displayed growth inhibitory effects. Among them, alpha-mangostin
showed complete inhibition at 10 microM through the induction of apoptosis.
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